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Dr Mohammad Reza Abbaszadegan
Professor of Medical Genetics
[at]mums.ac.ir
[at]yahoo.com
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Address: Division of Human Genetics, Avicenna Research Institute Mashhad University of
Medical Sciences Ferdosi Square, Bu-Ali Sq., Mashhad, Khorasan, Iran
Postal Code: 9196773117
Tel: (98-511) 38002414
Fax (98-511) 38002414
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und Educational Background
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Ph.D. in Pharmacology & Toxicology – Cancer Genetics
University of Arizona Medical Center, Tucson, Arizona 85721
Minor: Microbiology & Immunology
Major Advisor: William S. Dalton, M.D., Ph.D.
Dissertation: Molecular Mechanisms of Drug Resistance in Human Malignancies.
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Master of Science in Applied Microbiology
Northern Arizona University, Flagstaff, Arizona 86011
Major Advisor: Emmanuel T. Akporiaye, Ph.D.
Thesis: Tumoricidal Activity of Tumor Infiltrating T-lymphocytes Against EMT6 (mammary carcinoma) Tumor Cells, Following the Injection of Viable or Irradiated Tumor Cells
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Bachelor of Science in Microbiology
University of Montana, Missoula, Montana 59801
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Research Interests
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Cancer Genetics
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Medical Genetics
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Genomics
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Next Generation Sequencing
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Publications
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Mansouri M, Foroughmand AM, Abbaszadegan MR, Memar B, Mahmoodian R, Gholamin M; Expression analysis of CD44 isoforms S and V3, in patients with esophageal squamous cell carcinoma. IBJ 2014
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Mansouri A, Abbaszadegan MR, Sorouri Khorashad J, Memar B, Gholamin M; The expression levels of CD44V6 are correlated with tumor invasion in esophageal squamous cell Carcinoma patients . afinidad 2014
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Abbaszadegan MR, Faridhosseini R , Jabbariazad F ; Mansouri A, Shirkani A, Gholamin M; GATA3 Gene Polymorphisms Associated with Allergic Rhinitis in Iranian Population,
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Mansouri A, Abbaszadegan MR, Gholamin M; A Review on the Biology of Cancer Stem Cells. Stemcell discovery 2014
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Forghanifard MM, Gholamin M, Moaven M, Farshchian M, Ghahraman M, Aledavood A, Abbaszadegan MR; Neoantigen in esophageal squamous cell carcinoma for dendritic cell-based cancer vaccine development. Med Oncol 2014 Epub
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Ardalan khales S, Abbaszadegan MR, Abdollahi A, Raissosadati R, Fallah Tousi M, Forghanifard MM; SALL4 as a new biomarker for early colorectal cancers. J Cancer Res Clin Oncol 2014 Epub
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Taleb S, Abbaszadegan MR, Moghbeli M, Roudbari NH, Forghanifard MM.; HES1 as an Independent Prognostic Marker in Esophageal Squamous Cell Carcinoma.J Gastrointest Cancer. 2014 Epub
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Moghbeli M, Forghanifard MM, Abbaszadegan MR; Cancer stem cell detection and isolation. Med Oncol. 31(69)
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Kahkhaie KR, Moaven O, Abbaszadegan MR, Montazer M, Gholamin M. Specific MUC1 Splice Variants Are Correlated With Tumor Progression in Esophageal Cancer.World J Surg. 38(8):2052-7
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Daliri M, Abbaszadegan MR, Mehrabi Bahar M, Arabi A, Yadollahi M, Ghafari A, Taghehchian N, Zakavi SR. The role of BRAF V600E mutation as a potential marker for prognostic stratification of papillary thyroid carcinoma: a long-term follow-up study. Endocr Res. 2014 Mar 28
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Forghanifard MM, Ardalan Khales S, Javdani-Mallak A, Rad A, Farshchian M, Abbaszadegan MR. Stemness state regulators SALL4 and SOX2 are involved in progression and invasiveness of esophageal squamous cell carcinoma. Med Oncol, 3: 922 (2014)
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Raisossadati R, Abbaszadegan MR, Moghbeli M, Tavassoli A, Hiroaki Kihara A, Forghanifard MR; Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis. Tumor Biol, 35(6):5299-305 (2014).
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Presentations
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Abbaszadegan MR. Cancer Stem Cells. Medical Genetic Congress. Tehran, Iran, 2013
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Abbaszadegan MR. Probable genetic factors in Esophageal and gastric cancer epidemiology. International Multidisciplinary Cancer Congress.
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Abbaszadegan MR. Cancer stem cells. Medical Genetic Congeress. Tehran, Iran, 2012
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Abbaszadegan MR. Novel gene search in esophageal squamous cell carcinoma. The Third International Scientific and Practical Conference- postgenome 2012. Kazan, Russia, 2012.
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Raeisossadat R, Forghanifard M.M, Sardari S, Tavassoli A, Moghbeli M, Abbaszadegan MR. Developmental pluripotency associated- 2 (DPPA2) gene may be a metastatic marker for colorectal cancer. European Human Genetics Conference 2012. Nurnberg, Germany, 2012.
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Moghbeli M, Forghanifard M.M, Raeisossadat R, Broumand S, Abbaszadegan MR. HIWI as a prognostic marker for early stages of colorectal cancer. European Human Genetics Conference 2012. Nurnberg, Germany, 2012.
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Forghanifard M.M , Raeisossadat R, Moghbeli M, Tavassoli A, Montazar M, Gholamin M, Abbaszadegan MR. Elucidation of SALL4 oncogenic role in colorectal cancer; the first report. European Human Genetics Conference 2012. Nurnberg, Germany, 2012.
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Dadkhah E, Moghaddasian M, Arab H, Bustani Farkoush H, Kazemi Noughabi M, Abbaszadegan MR. Novel mutation in cathepsin C gene(CTSC) and modeling of mutated protein in three Iranian families with Papillon Lefever Syndrome. European Human Genetics Conference 2012.Nurnberg, Germany, 2012.
Abbaszadegan MR, Forghanifard MM. Impact of cancer testis antigens crosstalk with self renewal cell signaling pathways in esophageal squamous cell carcinoma. European Human Genetics Conference 2012.Nurnberg, Germany. June 23-26-2012. (Poster presentation).
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Abbaszadegan MR, Saidi R, Moaven M, A'rabi A, Homaie-Shandiz F. Novel germ line BRCA2 mutations in familial esophageal squamous cell carcinoma.12th Iranian Congress of biochemistry& 4th International Congress of Biochemistry and Molecular Biology, Mashhad, Iran, 2011.
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Abbaszadegan MR, Ahadian M, Keify F. Molecular genetics of autosomal recessive polycystic kidney disease. The 2nd International congress of Iranian Society of Pediatric Nephrology, Mashhad, Iran, 2011.
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Honors & Awards
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Sigma Xi, the Scientific Research Society
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National Institute of Health Intramural Research Training Award (IRTA)
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NIH Fellows Award for Research Excellence
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Khwarizmi First Award for Applied Medical Protocols (Congenital Adrenal Hyperplasia)
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Medical Geneticist: American Board of Medical Genetics, Board Eligible
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Members hip Membership
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American Society of Human Genetics
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American Association for the Advancement of Science
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Associate Member, American Association for Cancer Research
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Student/Fellow Member, American Society for Microbiology
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Administrative Responsibilities
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Assistant, Associate and now Professor, Medical Genetics Head, Medical Genetics Research Center Mashhad University of Medical Sciences Mashhad, Iran
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Assistant Professor Institute for Molecular & Human Genetics Georgetown University Medical Center 3800 Reservoir Road, 4 Main, M4000 Washingtion D.C. 20007
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Postdoctoral Fellow Diagnostic Development Branch National Center for Human Genome Research, NIH, Bethesda, Maryland 20892 Principal investigator: Mark R. Hughes, M.D., Ph.D. Project: Research and Development of new diagnostic assays for human genetic diseases, Prenatal & Preimplantation genetic diagnosis & Familial Breast Cancer
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Research Assistant II University of Arizona Medical Center, Tucson, Arizona 85721
Internal Medicine/Gastroenterology Principal investigator: David Earnest, M.D. Project: Studying the mechanism of vitamin A potentiation of xenobiotic hepatotoxicity; vitamin A activation of Kupffer cells in vitro and in vivo.
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Medical Technologist Public Health Service Indian Hospital, Tuba City, Arizona 86045 Laboratory Services Laboratory Manager: Bruce Gardner
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Other Skills
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SERVICE ACTIVITIES
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GRANTS & Licensing a Technology Primary Investigator
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Writing books
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